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New
Microfluidic Technology for Proteomic Research
April 1, 2008, Ithaca, NY – Advion BioSystems, a leading
supplier of microfluidic devices for the life sciences
industry, launches the latest advancements in proteomic
research - the Advion RePlay and FloTek systems.
RePlay is a new nanoLC tool that provides proteomic
researchers with two complementary MS analyses from one
injection. Suited for rapid identification of proteins
and structural identification of post translational
modifications, RePlay splits a chromatographic run into
two separations directing one to the MS for analysis
while simultaneously directing the other into the
Capture Cartridge. Once the initial MS analysis
completes, RePlay switches flow and the captured
chromatographic separation is then analyzed while the
nanoLC system reequilibrates thereby increasing mass
spectrometer utilization time while decreasing the need
for extra time and sample.
Compatible with all nanosprayers, including MS vendor
supplied sprayers, third party sprayers, pulled
capillaries, and the ESI Chip, RePlay is also compatible
with existing nanoLC systems and mass spectrometers.
Proteomics researchers have demonstrated that a second
analysis of the same sample can improve protein and
peptide coverage, increase identification of post
translational modifications, and improve analytical
confidence. Such repeat analysis provides more
information by allowing varied analytic conditions and
increased analysis time. However, the time for a single
nanoLC analysis is generally 60 minutes, and many
researchers do not have adequate amounts of sample or
time to invest in a reanalysis. RePlay allows the
researcher to obtain two analyses without a second
injection saving time and sample.
Matthias Mann, a scientific collaborator from the Max
Planck Institute, states “The RePlay device was
co-developed in our laboratory, and we believe it will
have a significant impact on proteomic research.”
Jennifer Busby, another RePlay user at Scripps Research,
adds, “In a proteomics service laboratory, time is
money. RePlay allows me to do more in the same amount of
time and thus, increase my mass spectrometer usage.”
Thomas Kurz, President of Commerical Operations,
comments on the product launch, “Advion is positioning
itself as a leader in microfluidic chemistry. There is a
large need in the low flow proteomics market for a
device that can improve information content of complex
samples, increase expensive mass spectrometer
utilization time, and maximize available sample. We have
developed RePlay as an add-on product to existing nanoLC/MS
systems to address all of these needs, and are pleased
with the data we have seen from our users.”
In addition to the RePlay device, Advion is releasing
FloTek, a digital nanoflow meter. FloTek allows nanoLC
users to quickly and accurately determine flow rates
from their existing nanoLC system, a crucial measurement
necessary for analysis. The FloTek device is intended to
monitor nanoLC performance as well as assist in
diagnosing nanoLC system issues. It can be used in
conjunction with RePlay or as a stand alone device.
Advion has received patent pending status of RePlay, and
is the sole supplier of this technology. Orders for the
RePlay and Flotek devices should be placed with a local
Advion account manager.
About Advion BioSystems, Inc.
Advion is the scientific leader in microfluidics
systems. The company’s scientific knowledge base creates
unique nanotechnologies delivering speed, flexibility,
and exceptional data quality. Advion is the
microfluidics supplier of choice for customers demanding
scientific excellence that provides better synthesis,
accurate mass analysis, higher yields and greater
throughput. More information about the company can be
found on their website at
www.advion.com.
Company Contact:
Amy Boardman
Corporate Marketing Communications Manager
Advion
607.266.0665 ext. 314
aboardman@advion.com
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